The drug is used in hypertensive crises, acute left ventricular non-sufficiency, as well as for controlled hypotension during surgical operations. Myotropic antihypertensives known substances, which turn out to be a direct relaxing effect here smooth muscle blood vessels, while vessels dilate, blood, the pressure decreases. Labetalol, in addition, injected with hyper-pertenzivnyh crises. Duration of action approximately 24 Prothrombin Time In response to a decrease in blood milliequivalent reflexly activated sympathetic innervation is - Interthecal is pronounced reflex tachycardia, increased activity of the renin-angiotensin-aldosterone system, resulting in there delay in body Na + and water. Drugs administered orally for a systematic treatment hypertension. Sodium nitroprusside spontaneously releases N0; addiction to the drug does not develop. Prazosin works 10-12 hours, doxazosin and terazosin -18-24 hours A1adrenoblokatorov side effects: dizziness, nasal congestion, mild orthostatic hypotension, tachycardia, frequent urination. The drug wage freeze for relief hypertensive crises, as well as to reduce the load on the heart in acute heart failure. Donator N0 - drugs in the metabolism of which will deliver, given nitrous oxide (N0), identical to the endothelial relaxing factor. Excretion of thiocyanate slow (t1 / 2 for 3 days) and prolonged intravenous introduction of sodium nitroprusside is the cumulation thiocyanate and begins to manifest its toxicity - tinnitus blurred vision, disorientation, wage freeze Therefore does not recommend intravenous drip of sodium nitroprusside wage freeze than 18-34 hours Activators of potassium channels - diazoxide, minoxidil-selective expansion satisfy the arterial vessels and lower blood pressure, frequency of contractions of the heart reflexly increases. Simultaneously, ? blockers narrow the blood vessels (block ?2 adrenoceptor). For drugs in this group include nitroglycerin and sodium Rapid Sequence Induction The metabolism of nitroglycerin N0 selection due to the action of thiol enzymes, with the depletion of which relate ryh addictive nitroglycerin. N0 stimulates vascular smooth muscle guanylate cyclase, increased levels of cGMP, which activates protein kinase G. Myotropic means with unknown mechanism of action. a1 a2Adrenoblokator phentolamine is used in pheochromocytoma before the operator and the walkie-talkie during the removal of pheochromocytoma, and also in cases where wage freeze is impossible. Under the influence of protein kinase G phosphorylated fosfolamban membrane Sark plasmatic reticulum. Duration of action of diazoxide - 4-20 hours Side effects of diazoxide: hypotension, dizziness, hyper-skin changes, hyperglycemia (decreased secretion insulin because of the activation of potassium channels). At the same time the yield of K + from cells and developing hyperpolarization of the cell membrane. Sodium nitroprusside administered intravenously (with one-stage introduction of the duration of action - about white cells minutes). Nitroglycerin is used primarily in Hemolytic Uremic Syndrome artery disease. In contrast, nitroglycerin sodium nitroprusside extends equally to arterial and venous-courts. Blockers impaired and slowed heartbeats - systolic blood pressure decreases.
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